Biological features of the clone involved in primary amyloidosis (AL)

Authors
Perfetti, V Vignarelli, MC Casarini, S Ascari, E Merlini, G
Citation
V. Perfetti et al., Biological features of the clone involved in primary amyloidosis (AL), LEUKEMIA, 15(2), 2001, pp. 195-202
Citations number
99
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA
ISSN journal
08876924 → ACNP
Volume
15
Issue
2
Year of publication
2001
Pages
195 - 202
Database
ISI
SICI code
0887-6924(200102)15:2<195:BFOTCI>2.0.ZU;2-L
Abstract
Primary light chain-associated amyloidosis (AL) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light ch ains in the form of fibrils (amyloid). It is the most common form of system ic amyloidosis in Western countries and is rapidly fatal. Knowledge of the pathobiology of the underlying B cell clone is of primary importance for th e design and optimization of therapeutic strategies.