Clinicopathological features of myeloid/natural killer (NK) cell precursoracute leukemia

Authors
Inaba, T Shimazaki, C Sumikuma, T Ochiai, N Okano, A Hatsuse, M Ashihara, E Kobayashi, Y Rin, K Murakami, S Haruyama, H Fujita, N Nakagawa, M
Citation
T. Inaba et al., Clinicopathological features of myeloid/natural killer (NK) cell precursoracute leukemia, LEUK RES, 25(2), 2001, pp. 109-113
Citations number
18
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
25
Issue
2
Year of publication
2001
Pages
109 - 113
Database
ISI
SICI code
0145-2126(200102)25:2<109:CFOMK(>2.0.ZU;2-B
Abstract
Four patients (three males and one female) were diagnosed as myeloid/natura l killer (NK) cell precursor acute leukemia in our department. Two patients showed the extramedullary involvement at initial presentation. Leukemic ce lls expressed CD7, CD33, CD45 and CD56 in all patients. Additionally, CD13, CD34, HLA-DR, cytoplasmic CD3 and myeloperoxidase were expressed in some p atients. Trisomy 10 was found in two patients, which has not been reported in this disease. Therefore, myeloid/NK cell precursor acute leukemia might be rather heterogeneous especially in chromosomal abnormality though it see med to constitute the distinct clinical entity among acute myeloid leukemia of MO subtype. (C) 2001 Elsevier Science Ltd. All rights reserved.