While the Course of technological change is widely accepted to be highly un
certain and unpredictable, little work has identified or studied the ultima
te sources and causes of that uncertainty. This paper proposes that purely
technological uncertainty derives from inventors' search processes with unf
amiliar components and component combinations. Experimentation with new com
ponents and new combinations leads to Less useful inventions on average, bu
t it also implies an increase in the variability that can result in both fa
ilure and breakthrough. Negative binomial count and dispersion models with
patent citation data demonstrate that new combinations are indeed more vari
able. Ln contrast to predictions, however, the reuse of components has a no
nmonotonic and eventually positive effect on variability.