Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behaviorin rats

Authors
Rudissaar, R Pruus, K Skrebuhhova-Malmros, T Allikmets, L Matto, V
Citation
R. Rudissaar et al., Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behaviorin rats, METH FIND E, 22(8), 2000, pp. 637-640
Citations number
30
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
ISSN journal
03790355 → ACNP
Volume
22
Issue
8
Year of publication
2000
Pages
637 - 640
Database
ISI
SICI code
0379-0355(200010)22:8<637:IOGNIT>2.0.ZU;2-B
Abstract
The effect of treatment with the acute GABA(A) receptor agonist THIP and th e GABA(B) receptor agonist baclofen on apomorphine-induced aggressive behav ior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and ba clofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine -induced aggressiveness. On the basis of our data it can be proposed that b oth GABA(A) and GABA(B) receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission. ( C) 2000 Prous Science. All rights reserved.