Most individuals with myasthenia gravis (MG) complain of cognitive impairme
nt, but empirical studies of cognition in MG have produced mixed results. I
n the present review, we critically examined the methodology and results of
previous studies that investigated cognition in MG. Results from our revie
w revealed that none of the studies met at least 50% of criteria under revi
ew. The most common shortcomings of previous studies included small sample
size, no exclusion for visual difficulties in patients, inadequate assessme
nt of mood, and poor control for prednisone use. Despite these methodologic
al difficulties, mild impairments on measures of learning have been identif
ied. These findings need to be replicated with adequate control of potentia
l confounds before any conclusions can be made regarding cognition in this
disease. Suggestions for design of future studies are provided. (C) 2001 El
sevier Science Ltd. All rights reserved.