Monosodium L-glutamate-induced obesity impaired the adrenal medullae activity

Impairment of sympathoadrenomedullar system has been suggested to have a ro le in obesity. The activity of adrenal medullae (AM) isolated from 90-day-o ld obese-induced L-monosodium glutamate (MSG) male mice was studied. MSG tr eatment induced obesity without hyperphagia, while MSG-animals were shorter and lighter than the controls. Catecholamines (CA) gland content decreased in MSG-mice, while secretory response to carbachol was similar in isolated AM of both groups. However, high extracellular potassium did not stimulate CA secretion on AM isolated from obese animals as occurred in controls. Ch olinesterase activity of adrenal glands homogenate was impaired in MSG-mice . Results suggest that MSG-hypothalamus lesions could cause impairment of s ympathetic transmission in AM, which impose less CA accumulation and alter secretion response in AM. These defects might be involved at the onset of M SG obesity.