Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor

Authors
Peters, MG Vanzulli, S Elizalde, PV Charreau, EH Goin, MM
Citation
Mg. Peters et al., Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor, ONCOL REP, 8(2), 2001, pp. 445-449
Citations number
21
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021335X → ACNP
Volume
8
Issue
2
Year of publication
2001
Pages
445 - 449
Database
ISI
SICI code
1021-335X(200103/04)8:2<445:EOARAZ>2.0.ZU;2-V
Abstract
This study links the tumor inhibitory effect of anti-progestins RU486 and Z K98299 to the expression of cell cycle proteins. Medroxyprogesterone acetat e-induced ductal mammary adenocarcinoma-bearing female BALB/c mice were tre ated daily either with RU486 or ZK98299, observing tumor growth retardation . p21 increased after 24 h treatment, peaked at day 4 and returned to contr ol levels at day 7. Cyclin D1, cyclin E, CDK2 and CDK4, did not change duri ng treatment. These results suggest that p21 might play a role in early inh ibitory stages of tumor growth induced by RU486 and ZK98299.