Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus

Citation
I. Rodriguez-nunez et al., Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus, ORAL SURG O, 91(2), 2001, pp. 180-188
Citations number
55
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
ISSN journal
10792104 → ACNP
Volume
91
Issue
2
Year of publication
2001
Pages
180 - 188
Database
ISI
SICI code
1079-2104(200102)91:2<180:PTSIPW>2.0.ZU;2-8
Abstract
Objective. Oral lichen planus (OLP) presents with various clinical forms th at can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between thes e 2 types. Study design. We investigated possible immunologic differences between 26 p atients with reticular OLP and 26 patients with atrophic-erosive OLP. Results. No differences were detected in serum Ig levels or complement leve ls. However, the mean proportions of CD4+CD45RO+ and DR+ lymphocytes were s ignificantly higher in patients with atrophic-erosive OLP than in patients with reticular OLP, whereas the mean proportion of CD8+CD45RA+ lymphocytes was significantly lower in patients with atrophic-erosive OLP. Conclusion. These findings suggest that the 2 clinical types of OLP might h ave different immunopathogenic mechanisms.