Nicorandil can induce severe oral ulceration

Objective. To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration. Study design. Nine new cases of ulceration from 3 European countries were i ncluded in this study. Results. Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No l esions developed on other epithelia. Conclusions. A number of drugs used in the care of patients with cardiovasc ular disease can cause oral adverse effects. Nicorandil, a new potassium-ch annel activator used in some countries to treat angina pectoris, precipitat es persistent ulcerative stomatitis in some patients.