Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals

Authors
Cosp, A Romea, P Talavera, P Urpi, F Vilarrasa, J Font-Bardia, M Solans, X
Citation
A. Cosp et al., Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals, ORG LETT, 3(4), 2001, pp. 615-617
Citations number
35
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
4
Year of publication
2001
Pages
615 - 617
Database
ISI
SICI code
1523-7060(20010222)3:4<615:EAOACT>2.0.ZU;2-O
Abstract
[GRAPHICS] High stereoselectivities (up to 98% de) have been achieved for the Lewis ac id mediated cross-coupling reaction of dimethyl acetals to a chiral 1,3-thi azolidine-2-thione-derived titanium enolate. The reaction affords enantiopu re anti alpha -methyl-beta -alkoxy carbonyl compounds in a wide range of ac etals.