Intracranial hemorrhage at the onset of thrombotic thrombocytopenic purpura in an infant: Therapeutic approach and intensive care management

Thrombotic thrombocytopenic purpura (TTP) is quite rare in infancy and must be treated intensively as a Life-threatening disease, Diffuse vascular thr omboses may occur, and neurologic involvement is a cornerstone of the diagn osis of TTP. We describe a case of an infant who presented with a sudden ce rebral hemorrhage and subsequently developed the typical clinical features of TTP. Emergency treatment in the Pediatric Intensive Care Unit (PICU) con sisted of plasma therapy and exchange-transfusion (EXT) to arrest the intra vascular process and the exsanguinating blood loss. Exchange-transfusion is a life-saving procedure that is rarely performed after the neonatal age.