Changes in metalloproteinase (MMP-1, MMP-2) expression in the proximal region of the varicose saphenous vein wall in young subjects

Objective: An evaluation of the proteoglycan perlecan, collagen I and III, and metalloproteinases MMP-1, -2, -3 and -9 was performed to explore the po ssible relationships between ageing, affected vein region and reactive stat e of the varicose vein wall. Methods: Segments of saphenous vein were obtained from healthy subjects and from those with varicose veins. The vein specimens were subdivided accordi ng to subject age (<50/<greater than or equal to>50) and vein source (dista l/proximal). Results: The walls of control vein specimens acquired a more collagenous ap pearance with age. These changes were not accompanied by significant modifi cations in the immunohistochemical markers used. In specimens from young pa tients, proximal varicose vein segments showed an increase in MMP-1, MMP-2 and MMP-9 expression. Subjects of more advanced age showed an increase in p erlecan expression. Conclusion: This increase in MMPs could lead to the acceleration of the fin al fibrosclerotic process characteristic of the varicose vein wall.