In Randall-Sundrum-type brane-world cosmologies, density perturbations gene
rate a Weyl curvature in the bulk, which in turn back reacts on the brane v
ia stress-energy perturbations. On large scales, the perturbation equations
contain a closed system on the brane, which may be solved without solving
for the bulk perturbations. Bulk effects produce a nonadiabatic mode, even
when the matter perturbations are adiabatic, and alter the background dynam
ics. As a consequence, the standard evolution of large-scale fluctuations i
n general relativity is modified. The metric perturbation on large-scales i
s not constant during high-energy inflation. It is constant during the radi
ation era, except at most during the very beginning, if the energy is high
enough.