Choroidopathy in patients with sarcoidosis observed by simultaneous indocyanine green and fluorescein angiography

Purpose: To examine choroidopathy in patients with sarcoidosis. Methods: In a prospective clinical study, 10 consecutive patients (20 eyes) with sarcoidosis underwent simultaneous indocyanine green (ICG) and fluore scein angiography (FA) with a double detector of scanning laser ophthalmosc opy. Angiographic findings recorded on videotapes were evaluated, and the r elation of ICG angiographic findings with systemic activity and the extent of retinal inflammation was analyzed. Results: Indocyanine green angiographic findings, not evident with fluoresc ein, were multiple lobular hypofluorescent spots in the posterior pole in 1 0 eyes of 5 patients, isolated hypofluorescent plaques in 2 eyes of 1 patie nt, hyperfluorescent spots in 3 eyes of 2 patients, and segmental choroidal vascular wall staining in 6 eyes of 4 patients. The multiple lobular hypof luorescent spots with ICG were observed at a significantly higher rate in e yes with extensive retinal vascular leakage of fluorescein than in eyes wit h minimal leakage (chi-square test, P = 0.0007). Conclusions: The patients with sarcoidosis showed choroidal abnormalities t hat could be revealed by ICG angiography, but not by funduscopy or FA. Simu ltaneous ICG and FA angiography may be useful for examining choroidal lesio ns in sarcoidosis.