Cs. De La Calzada et al., Guidelines of the Spanish Society of Cardiology for pulmonary thromboembolism and hypertension, REV ESP CAR, 54(2), 2001, pp. 194-210
Primary pulmonary hypertension is a progressive disease. Most affected pati
ents are young and middle-aged women. Etiology is unknown, although a famil
ial and genetic factor is present in up to 6% of cases. Endothelial dysfunc
tion and abnormalities in calcium channels of smooth muscle fibers are the
present pathogenetics theories. Diagnostic tests try to exclude secondary c
auses of pulmonary hypertension and to evaluate its severity. Acute vasodil
atory test is vital in the selection of treatment. Oral anticoagulation is
indicated in all patients. Lung transplant is performed when medical treatm
ent is unsuccessful. Atrial septostomy is an alternative and palliative tre
atment for selected cases. Chronic thromboembolic pulmonary hypertension is
a special form of secondary pulmonary hypertension, clinically undistinguis
hable from primary primary hypertension, is of mandatory diagnosis because
it can be cured with thromboembolectomy.
Pulmonary embolism is common in hospitalised patients. The mortality rate f
or pulmonary embolism continues to be high: up to 30% in untreated patients
. The accurate detection of pulmonary embolism remains difficult, as pulmon
ary embolism can accompany as well as mimic other cardiopulmonary illnesses
. Non-invasive diagnostic tests have poor specificity and sensitivity. The
D-dimer level and the spiral CT angiography have also been employed as new
alternatives and important tools for precise diagnosis of suspected pulmona
ry embolism. The standard therapy of pulmonary embolism is intravenous hepa
rin for 5 to 10 days in conjunction with oral anticoagulants posteriorly fo
r 3 to 6 months. The incidence of deep venous thrombosis, pulmonary embolis
m and death due to pulmonary embolism, can be reduced significantly and sho
wn clear benefits only by adoption of a prophylactic strategy with low-mole
cular-weight-heparins or dextrans in patients at risk.