Aim: To give recommendations for the standard diagnostic assessment of uret
hral diverticula and periurethral masses based on an evaluation of our resu
lts and a survey of the recent literature. Methods: Group I (1981-1993) inc
luded 47 women in whom urethral diverticula (n=34), periurethral cysts (n=1
1), and periurethral leiomyomas (n=2) were diagnosed and the results compar
ed with the intraoperative findings. Diagnostic work-up comprised history t
aking, vaginal palpation, introitus ultrasound, double-balloon urethrograph
y (DBU), voiding cystourethroscopy (VCU), excretion urography (EU), and ure
throcystoscopy. Group II (1994-1996) included 12 women with urethral divert
icula who were examined by DBU, 2D and 3D introitus ultrasound. The diagnos
tic accuracy of the different methods was assessed. Results: Group I: The d
iagnostic accuracy in identifying urethral diverticula was 85.3% for palpat
ion, 61.5% for introitus ultrasound, 93.8% for DBU, 37.5% for EU, and 30.0%
for urethrocystoscopy. Of all imaging modalities used, only introitus ultr
asound depicted periurethral cysts and leiomyomas. Group II: The DBU, 2D an
d 3D introitus ultrasound had a diagnostic accuracy of 100% in identifying
urethral diverticula. Conclusions: Introitus ultrasound should be used as t
he basic diagnostic tool in clinically suspected urethral diverticula or pe
riurethral masses and additional DBU should be restricted to cases with inc
onclusive findings.