Centrosome-dependent exit of cytokinesis in animal cells

As an organelle coupling nuclear and cytoplasmic divisions, the centrosome is essential to mitotic fidelity, and its inheritance could be critical to understanding cell transformation. Investigating the behavior of the centro some in Living mitotic cells, we documented a transient and remarkable post anaphase repositioning of this organelle, which apparently controls the rel ease of central microtubules from the midbody and the completion of cell di vision. We also observed that the absence of the centrosome Leads to defect s in cytokinesis. Together with recent results in yeasts, our data point to a conserved centrosome-dependent pathway that integrates spatial controls into the decision of completing cell division, which requires the repositio ning of the centrosome organelle.