Molecular structure and affinity to 5-HT1A receptor of chlorophenyl(piperazinylalkyl)phthalimides

Authors
Chumakov, YM Simonov, YA Soboleva, SG Sava, VM Andronati, SA Gdaniec, M Bocelli, G
Citation
Ym. Chumakov et al., Molecular structure and affinity to 5-HT1A receptor of chlorophenyl(piperazinylalkyl)phthalimides, SUPRAMOL CH, 12(2), 2000, pp. 225-227
Citations number
6
Categorie Soggetti
Chemistry
Journal title
SUPRAMOLECULAR CHEMISTRY
ISSN journal
10610278 → ACNP
Volume
12
Issue
2
Year of publication
2000
Pages
225 - 227
Database
ISI
SICI code
1061-0278(2000)12:2<225:MSAAT5>2.0.ZU;2-Y
Abstract
X-ray crystallography, quantum-chemical calculations and conformational ana lysis have been employed to study chlorophenyl(piperazinylalkyl)phthalimide s, potential ligands of 5-HT1A receptor. The molecular recognition of inves tigated compounds by 5-HT(1A)serotonin receptor has been estimated accordin g to their ability to inhibit the [(3)H8]-DPAT binding. The model for 5-HT1 A pharmacophore has been proposed based on crystal structures of N-(aryl)pi perazinyl - alkylphthalimides.