Intramolecular trapping of amides by 1-lithio-1-bromocyclopropanes

Authors
Baird, MS Huber, FAM Tverezovsky, VV Bolesov, IG
Citation
Ms. Baird et al., Intramolecular trapping of amides by 1-lithio-1-bromocyclopropanes, TETRAHEDRON, 57(8), 2001, pp. 1593-1600
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
8
Year of publication
2001
Pages
1593 - 1600
Database
ISI
SICI code
0040-4020(20010218)57:8<1593:ITOAB1>2.0.ZU;2-N
Abstract
Reaction of 2-acylaminomethyl-1,1-dibromocyclopropanes with methyllithium a t -90 degreesC leads to selective bromine-lithium exchange and cyclisation to give a 1-bromo-3-azabicyclo[3.1.0]hexan-2-ol. (C) 2001 Elsevier Science Ltd. All rights reserved.