Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones

Authors
Al-Awadi, NA Elnagdi, MH Ibrahim, YA Kaul, K Kumar, A
Citation
Na. Al-awadi et al., Efficient synthesis of 3-aroylcinnolines from aryl methyl ketones, TETRAHEDRON, 57(8), 2001, pp. 1609-1614
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
8
Year of publication
2001
Pages
1609 - 1614
Database
ISI
SICI code
0040-4020(20010218)57:8<1609:ESO3FA>2.0.ZU;2-3
Abstract
An efficient synthesis of 3-aroylcinnolines starting from the appropriate a ryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid ca talyzed cyclization in cone. sulfuric acid or polyphosphoric acid (PPA) led to the corresponding 3-aroylcinnolines. (C) 2001 Elsevier Science Ltd. All rights reserved.