A facile synthesis of 2-oxazolidinones via Hofmann rearrangement mediated by bis(trifluoroacetoxy)iodobenzene

Authors
Yu, CZ Jiang, YY Liu, B Hu, LQ
Citation
Cz. Yu et al., A facile synthesis of 2-oxazolidinones via Hofmann rearrangement mediated by bis(trifluoroacetoxy)iodobenzene, TETRAHEDR L, 42(8), 2001, pp. 1449-1452
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
8
Year of publication
2001
Pages
1449 - 1452
Database
ISI
SICI code
0040-4039(20010219)42:8<1449:AFSO2V>2.0.ZU;2-H
Abstract
A mild and efficient synthesis of 2-oxazolidinones from beta -hydroxypropio namides via Hofmann rearrangement was achieved in 96% to quantitative yield using bis(trifluoroacetoxy)iodobenzene (BTI) in acetonitrile. The method s hould be useful in both solution- and solid-phase construction of 2-oxazoli dinone libraries. (C) 2001 Published by Elsevier Science Ltd.