Stereoselective synthesis of 2-amino-5-hydroxycaprolactams from L-glutamicacid

Authors
Roche, D Prasad, K Repic, O Blacklock, TJ
Citation
D. Roche et al., Stereoselective synthesis of 2-amino-5-hydroxycaprolactams from L-glutamicacid, TETRAHEDR L, 42(8), 2001, pp. 1459-1462
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
8
Year of publication
2001
Pages
1459 - 1462
Database
ISI
SICI code
0040-4039(20010219)42:8<1459:SSO2FL>2.0.ZU;2-7
Abstract
A five-step stereoselective synthesis of both (2S,5S)- and (2S,SR)-2-amino- 5-hydroxycaprolactam has been achieved via the aldol reaction of L-glutamic aldehyde 1 with nitromethane. (C) 2001 Elsevier Science Ltd. All rights re served.