New approach to the epimeric analogue of cyclic peptides: epimerisation via oxazoles of RA-VII, an anti-tumour bicyclic hexapeptide from Rubia plants

Authors
Hitotsuyanagi, Y Matsumoto, Y Sasaki, S Yamaguchi, K Itokawa, H Takeya, K
Citation
Y. Hitotsuyanagi et al., New approach to the epimeric analogue of cyclic peptides: epimerisation via oxazoles of RA-VII, an anti-tumour bicyclic hexapeptide from Rubia plants, TETRAHEDR L, 42(8), 2001, pp. 1535-1537
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
8
Year of publication
2001
Pages
1535 - 1537
Database
ISI
SICI code
0040-4039(20010219)42:8<1535:NATTEA>2.0.ZU;2-N
Abstract
[D-Ala-4]RA-VII (9) and [D-Ala-2]RA-VII (10) were prepared from RA-VII (1), an anti-tumour bicyclic hexapeptide from Rubia plants, by conversion of it s thioamide 3 into oxazoles 4 and 5 and subsequent acid-catalysed hydrolysi s. (C) 2001 Elsevier Science Ltd. All rights reserved.