Asymmetric hydrogenation of enamides with catalysts containing chiral thiourea ligands

Authors
Tommasino, ML Casalta, M Breuzard, JAJ Lemaire, M
Citation
Ml. Tommasino et al., Asymmetric hydrogenation of enamides with catalysts containing chiral thiourea ligands, TETRAHEDR-A, 11(24), 2000, pp. 4835-4841
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
24
Year of publication
2000
Pages
4835 - 4841
Database
ISI
SICI code
0957-4166(200012)11:24<4835:AHOEWC>2.0.ZU;2-D
Abstract
The asymmetric reduction of enamides with molecular, hydrogen and catalytic amounts of rhodium, iridium or ruthenium complexes containing chiral N,S-l igands is reported. Various enantiomerically pure mono- and dithioureas wer e examined. The C-2-symmetry of the dithiourea ligands seems essential to t he enantioselectivity achieved. Ee values of up to 70% were observed. (C) 2 001 Elsevier Science Ltd. All rights reserved.