The E27 beta(2)-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males

In the present study we evaluated whether two polymorphisms of beta (2)-adr energic receptors (beta (2)-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients wh o had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E wer e: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in t he control group. There was a trend (not statistically significant) of decr easing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P<0.001) compared with normolipide mia in the entire study population, the relative risk increased to 9.0 (P<0 .001) in Q27 homozygotes with dyslipidemia, and decreased to 1.8 (P=0.36) i n E27 homozygotes. Our results show that the E27 allele of the beta (2)-adrenergic receptor ha s a significant protective effect on MI in dyslipidemic young male.