Innovative technologies for the diagnosis of alcohol abuse and monitoring abstinence

This article summarizes the proceedings of a workshop presented at the 2000 RSA Meeting in Denver, Colorado. The aim of this workshop was to discuss t he basic methodologies, diagnostic performance, and clinical utility of thr ee technologies: carbohydrate-deficient transferrin, the "Early Detection o f Alcohol Consumption" score, and whole blood associated acetaldehyde. Each method adopts a different strategy to identify heavy alcohol consumption a nd offers a unique approach to determine alcohol abstinence and relapses. A ppropriate application of these technologies can lead to early intervention for alcohol problems before significant tissue damage occurs. To date thes e methodologies have yet to be formally contrasted and compared. Sensitivit y, specificity, predictive value, availability, ease of use, and interpreta tion of tests results are important aspects to consider when selecting the most appropriate and cost-effective system. Critical evaluation of these me thodologies can enable research and clinical laboratories to choose the sys tem that best meets their particular needs in terms of assay feasibility, b udget, and goals.