Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores

Background: Although iron deficiency occurs commonly in vulnerable groups o f women of reproductive age, infants, and children, less is known about the iron nutriture of the elderly. Objective: Our objective was to evaluate the iron status of a noninstitutio nalized, elderly US population, with a particular focus on 2 concerns uniqu e to the elderly: 1) potential confounding effects of chronic disease on ir on measures and 2) increased occurrence of elevated iron stores. Design: Multiple iron measures, including serum ferritin (SF), transferrin saturation, mean cell volume, and hemoglobin, were used to evaluate the pre valence of iron deficiency (ID), iron deficiency anemia (IDA), and other me asures of iron nutriture in 1016 elderly white Americans aged 67-96 y from the Framingham Heart Study. "Diseased" subjects were defined as those with possible pathologically altered iron measures due to inflammation, infectio n, elevated liver enzymes, hereditary hemochromatosis, or cancer. The effec t of altered iron status on various prevalence estimates was assessed. Results: The elderly subjects had a low prevalence of ID (2.7%), IDA (1.2%) , and depleted iron stores (3%; SF < 12 <mu>g/L) In contrast, 12.9% had ele vated iron stores (SF > 300 mug/L in men and SF > 200 mug/L in women), of w hich only 18 was attributable to chronic disease. The prevalence of ID, IDA , and depleted iron stores was unaffected by the presence of chronic diseas e. Conclusions: The Framingham Heart Study cohort is an iron-replete elderly p opulation with a high prevalence of elevated iron stores in contrast with a low prevalence of iron deficiency, with insignificant effects of chronic d isease on these iron status estimates. The Likely liability in iron nutritu re in free-living, elderly white Americans eating a Western diet is high ir an stores, not iron deficiency.