Be. Van Beers et al., Hepatic perfusion parameters in chronic liver disease: Dynamic CT measurements correlated with disease severity, AM J ROENTG, 176(3), 2001, pp. 667-673
Citations number
36
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
OBJECTIVE. The aim of our study was to determine if hepatic perfusion param
eters measured with CT change in relation to disease severity in patients w
ith chronic liver disease.
SUBJECTS AND METHODS. Dynamic contrast-enhanced single-section CT scans of
the liver were obtained in 40 individuals who included six control subjects
, 16 patients with noncirrhotic chronic liver disease, and 18 patients with
cirrhosis. Hepatic, aortic, and portal venous time-density curves were fit
ted to a dual-input one-compartment model to calculate the liver perfusion,
arterial fraction, distribution volume, and mean transit time.
RESULTS. Liver perfusion decreased in patients with cirrhosis (67 +/- 23 mt
min(-1) 100 mL(-1) versus 108 +/- 34 mL . min(-1) . 100 mL(-1) in control
subjects [p = 0.009] and 98 +/- 36 mt min(-1) . 100 mL(-1) in patients with
noncirrhotic chronic liver disease [p = 0.003]), and the arterial fraction
and the mean transit time increased (41 +/- 27% and 51 +/- 79 sec versus 1
7 +/- 16% and 16 +/- 5 sec in control subjects, and 19 +/- 6% and 17 +/- 8
sec in patients with noncirrhotic chronic liver disease [p < 0.05]). A sign
ificant correlation was seen between these three perfusion parameters and t
he severity of chronic liver disease based on clinical and biologic data (p
< 0.001). No significant change in distribution volume was observed.
CONCLUSION. Hepatic perfusion parameters measured with CT were significantl
y altered in cirrhosis and correlated with the severity of chronic liver di
sease.