Hepatic perfusion parameters in chronic liver disease: Dynamic CT measurements correlated with disease severity

Citation
Be. Van Beers et al., Hepatic perfusion parameters in chronic liver disease: Dynamic CT measurements correlated with disease severity, AM J ROENTG, 176(3), 2001, pp. 667-673
Citations number
36
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN journal
0361803X → ACNP
Volume
176
Issue
3
Year of publication
2001
Pages
667 - 673
Database
ISI
SICI code
0361-803X(200103)176:3<667:HPPICL>2.0.ZU;2-O
Abstract
OBJECTIVE. The aim of our study was to determine if hepatic perfusion param eters measured with CT change in relation to disease severity in patients w ith chronic liver disease. SUBJECTS AND METHODS. Dynamic contrast-enhanced single-section CT scans of the liver were obtained in 40 individuals who included six control subjects , 16 patients with noncirrhotic chronic liver disease, and 18 patients with cirrhosis. Hepatic, aortic, and portal venous time-density curves were fit ted to a dual-input one-compartment model to calculate the liver perfusion, arterial fraction, distribution volume, and mean transit time. RESULTS. Liver perfusion decreased in patients with cirrhosis (67 +/- 23 mt min(-1) 100 mL(-1) versus 108 +/- 34 mL . min(-1) . 100 mL(-1) in control subjects [p = 0.009] and 98 +/- 36 mt min(-1) . 100 mL(-1) in patients with noncirrhotic chronic liver disease [p = 0.003]), and the arterial fraction and the mean transit time increased (41 +/- 27% and 51 +/- 79 sec versus 1 7 +/- 16% and 16 +/- 5 sec in control subjects, and 19 +/- 6% and 17 +/- 8 sec in patients with noncirrhotic chronic liver disease [p < 0.05]). A sign ificant correlation was seen between these three perfusion parameters and t he severity of chronic liver disease based on clinical and biologic data (p < 0.001). No significant change in distribution volume was observed. CONCLUSION. Hepatic perfusion parameters measured with CT were significantl y altered in cirrhosis and correlated with the severity of chronic liver di sease.