The addition of morphine prolongs fentanyl-bupivacaine spinal analgesia for the relief of labor pain

Citation
Hm. Yeh et al., The addition of morphine prolongs fentanyl-bupivacaine spinal analgesia for the relief of labor pain, ANESTH ANAL, 92(3), 2001, pp. 665-668
Citations number
18
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ANESTHESIA AND ANALGESIA
ISSN journal
00032999 → ACNP
Volume
92
Issue
3
Year of publication
2001
Pages
665 - 668
Database
ISI
SICI code
0003-2999(200103)92:3<665:TAOMPF>2.0.ZU;2-7
Abstract
The combination intrathecal fentanyl (25 mug) and bupivacaine (2.5 mg) prov ides effective labor analgesia for approximately 90 minutes. The purpose of this prospective, randomized, double-blinded investigation was to determin e if the addition of morphine (150 mug) to the intrathecal combination of f entanyl (25 mug) and bupivacaine (2.5 mg) would prolong labor analgesia. By using the combined spinal epidural technique, 95 healthy primiparous labor ing women in early labor received 2 mL of one of the two intrathecal study solutions, either FB (n = 48): fentanyl (25 mug) and bupivacaine (2.5 mg); or FBM (n = 47): fentanyl (25 mug) and bupivacaine (2.5 mg) plus morphine ( 150 mug). The mean duration of labor analgesia was significantly longer in the FBM group than in the FB group (252 +/- 63 min vs 148 +/- 44 min, P < 0 .01). There were no significant differences between the two groups regardin g the sensory levels, the incidence of nausea, vomiting, pruritus, hypotens ion, or operative delivery. In conclusion, the addition of 150 <mu>g of mor phine to the intrathecal combination of fentanyl plus bupivacaine prolonged the duration of labor analgesia duration without increasing adverse effect s.