In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

Authors
Boos, M Mayer, S Fischer, A Kohrer, K Scheuring, S Heisig, P Verhoef, J Fluit, AC Schmitz, FJ
Citation
M. Boos et al., In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus, ANTIM AG CH, 45(3), 2001, pp. 938-942
Citations number
44
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
938 - 942
Database
ISI
SICI code
0066-4804(200103)45:3<938:IVDORT>2.0.ZU;2-H
Abstract
Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin , gatifloxacin, moxifloxacin, clinafloxacin, and gemifloxacin during a 10-d ay period. Subculturing led to resistance development, regardless of the in itial potencies of the quinolones. None of the quinolones was associated wi th a significantly slower rate of resistance development.