Efficacy of an evernimicin (SCH27899) in vitro and in an animal model of Lyme disease

Authors
Pavia, CS Wormser, GP Nowakowski, J Cacciapuoti, A
Citation
Cs. Pavia et al., Efficacy of an evernimicin (SCH27899) in vitro and in an animal model of Lyme disease, ANTIM AG CH, 45(3), 2001, pp. 936-937
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
936 - 937
Database
ISI
SICI code
0066-4804(200103)45:3<936:EOAE(I>2.0.ZU;2-R
Abstract
The MICs of evernimicin at which 90% of Borrelia burgdorferi patient isolat es were inhibited ranged from 0.1 to 0.5 mug/ml. Evernimicin was as effecti ve as ceftriaxone against B, burgdorferi in a murine model of experimental Lyme disease. As assessed by culturing the urinary bladders of infected C3H mice, no live Borrelia isolates were recoverable following antibiotic trea tment.