In vitro uptake of SCH 27899 (evernimicin) by rat alveolar macrophages

Authors
Zbaida, S Brieland, J Krieter, P Loebenberg, D Krishna, G Horne, D Lu, XW Yuan, Y Hare, R Cayen, MN Patrick, JE
Citation
S. Zbaida et al., In vitro uptake of SCH 27899 (evernimicin) by rat alveolar macrophages, ANTIM AG CH, 45(3), 2001, pp. 959-961
Citations number
7
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
959 - 961
Database
ISI
SICI code
0066-4804(200103)45:3<959:IVUOS2>2.0.ZU;2-#
Abstract
The in vitro uptake of [C-14]evernimicin ([C-14]SCH 27899) by primary cultu res of rat alveolar macrophages and hepatocytes was determined. Both cell p opulations exhibited linear rates of uptake. However, the initial rate of d rug uptake by alveolar macrophages was about threefold higher than that by hepatocytes. These findings demonstrate that [C-14]evernimicin is taken up by rat alveolar macrophages, supporting the likelihood that the drug is abl e to reach sites of infection.