Diethyl- and dibutyltin dihalide complexes of 1-methyl-2(3H)-imidazolinethione: synthesis, structure and antibacterial activity

The compounds [SnR2X2(Hmimt)] (R = Et, Bu; X = CI, Br; Hmimt = 1-methyl-2 ( 3H)-imidazolinethione) and [SnEt2X2(Hmimt)(2)] (X = Cl, Br) have been prepa red and characterized by elemental analysis, mass spectrometry and ER, Rama n, Mossbauer and NMR (H-1, C-13 and Sn-119) spectroscopy, An X-ray study of the crystal structure of [SnEt2Cl2(Hmimt)(2)] shows all-trans octahedral s tereochemistry with the tin atom coordinated to two ethyl carbon atoms, two chlorine atoms and the sulfur atoms of the two Hmimt ligands, Hmimt exhibi ts antibacterial activity against Bacillus subtilis (MIC = 6.25 mug ml(-1)) , and all the complexes inhibit the growth of Escherichia coli and Staphylo coccus aureus as well as B, subtilis with MIC values of 12.5 mug ml(-1) 6.2 5 mug ml(-1) and 3.12 mug ml(-1) respectively, for the most active complex, [SnBu2Cl2(Hmimt)]. Only [SnEt2Cl2(Hmimt)] shows activity against pseudomon as aeruginosa (MIC = 50 mug ml(-1)). Copyright (C) 2001 John Wiley & Sons, Ltd.