Synthesis, antitumor activity and crystal structure of the triphenyltin derivative of exo-7-oxa-bicyclo[2,2,1]hept-5-ene-3-N-p-tolylamide-2-acid

The synthesis and crystal structure of Ph3SnO2CCHCHCH:CHCH(O)CHCONHC6H4 CH3 . CH2Cl2 are reported. The monomer units are bridged by the carbonyl oxygen of the amide group, thus forming a polymer in which each tin atom is best described as having a distorted five-coordinate geometry. There is a relati vely strong intramolecular hydrogen bond between the amide hydrogen and the ether oxygen. The in vitro antitumor activities of the title compound agai nst HL-60, BGC-823, Bel-7402, SKOV3, KB and Hela tumor lines are reported. The title compound shows a distinct advantage when the metal (tin) is intro duced into the acid. Copyright (C) 2001 John Wiley & Sons, Ltd.