Synthesis and antihypertensive activity of certain Mannich Bases of 2-ethoxycarbonylindoles and 5H-pyridazino[4,5-b]indales

This manuscript reports the synthesis of two series of Mannich Bases 3-12 a nd 21-40 obtained respectively by the reaction of either 2-ethoxycarbonylin doles 1-2 or 5H-pyridazino [4,5-b]inoles 17-20 as a substrate with formalin and the appropriate 2 degrees amines under the suitable Mannich conditions . Fourteen of the synthesized Mannich basese were screened as antihypetensi ve agents in normotensive anesthetized rats. The effect of compound 4 in no rmotensive anesthetized dogs was also studied.