Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten

Authors
Han, YN Choo, Y Lee, YC Moon, YI Kim, SD Choi, JW
Citation
Yn. Han et al., Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten, ARCH PH RES, 24(1), 2001, pp. 51-54
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
24
Issue
1
Year of publication
2001
Pages
51 - 54
Database
ISI
SICI code
0253-6269(200102)24:1<51:MOBIFT>2.0.ZU;2-S
Abstract
Three varieties of methyl citrate and 1-methyl malate were isolated from th e fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioas say-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of l-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively . However, on MAO-A, their inhibitions showed only marginal activity.