Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: A gene family including the gene for prolactin-inducible protein
M. Yoshida et al., Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: A gene family including the gene for prolactin-inducible protein, BIOC BIOP R, 281(1), 2001, pp. 94-100
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
We cloned two new paralogous genes that encode proteins homologous to semin
al vesicle autoantigen (SVA) in rodents. The open reading frame of one mous
e gene encodes a polypeptide consisting of 151 amino acid residues which ha
s 43% identity to SVA, RT-PCR analysis showed selective expression in the c
olon, and thus the protein was tentatively named "SVA--lke protein in the c
olon (SLP-C)". The other mouse gene has an open reading frame encoding 144
amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively
Expression of this gene was detected in the mammary, submaxillary, parotid
, and lacrimal glands, and this protein was named "SLP in the mammary gland
(SLP-M)". Orthologs of both genes were also found in rats. The three homol
ogous genes coding for SVA, SEP-C, and SLP-M may have been generated by gen
e duplication with divergence of tissue expression in the course of evoluti
on. They comprise a unique structurally-related gene family. Moreover, thes
e genes share significant sequence homology with that of another secretory
glycoprotein, prolactin-inducible protein. (C) 2001 Academic Press.