Metabolism-resistant bradykinin antagonists: Development and applications

Bradykinin plays many roles in normal and pathological physiology, but rapi d enzymatic degradation made elucidation of its functions extremely difficu lt. Development of effective degradation-resistant antagonists made it poss ible to delineate these roles and to open the way for development of new dr ugs to control pathology due to excess production of bradykinin. Presently available peptide bradykinin antagonists are extremely potent, are complete ly resistant to enzymatic degradation, and are orally available. Non-peptid e bradykinin antagonists have also been discovered. Development of bradykin in antagonists as drugs for cancer, inflammation acid trauma is anticipated .