Microwave assisted solid support synthesis of novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazepines as potent antimicrobial agents

An environmentally benign and economic synthesis of 1,2,4-triazolo[3,4-b]-1 ,3,4-thiadiazepines is described from readily accessible substituted 2-merc apto-1-amino triazoles and substituted chalcones on basic alumina that are accelerated by exposure to microwaves. The reaction time has been brought d own from hours to seconds with improved yield as compared to conventional h eating. The method reported herein is devoid of the hazards of solution pha se reactions. All the synthesised compounds were tested for their in vitro antibacterial and antifungal activity. Some compounds showed significant an timicrobial properties. The best activity was observed with compounds 3a, 3 c, 4a and 4d. (C) 2001 Elsevier Science Ltd. All rights reserved.