CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor

Tumor cells of patients with cutaneous T-cell lymphoma (CTCL) have the cell surface phenotype of mature T-helper lymphocytes, and it may be impossible to differentiate them from nonmalignant lymphocytes in skin and blood. Unt il now, no specific cell membrane marker of CTCL has been reported. In the current study, it is reported for the first time that CTCL cells express th e major histocompatibility complex class I binding p140-killer cell immunog lobulin-like receptor, which has been described on a minor subset of natura l kilter lymphocytes and on a marginal circulating CD8(+) T lymphocyte subs et. Interestingly, the molecular characterization of this KIR expressed by CTCL allowed us to isolate a novel allelic form of p140-KIR3DL, resulting i n 4 amino acid substitutions, 3 in the extracellular immunoglobulin-like do main of the protein and one in the cytoplasmic region. This finding is like ly to be important both for the pathophysiology and for the clinical treatm ent of patients with CTCL. (Blood, 2001;97: 1388-1391) (C) 2001 by The Amer ican Society of Hematology.