A randomized comparison of 4 weeks of terbinafine vs. 8 weeks of griseofulvin for the treatment of tinea capitis

Background Tinea capitis is a common childhood infection that has recently become more frequent in urban areas in Europe and the U.S.A. The current li censed treatment in children is griseofulvin 10 mg kg(-1) daily, which is u sually given for 6-8 weeks. Objectives To compare this treatment with a 4-week course of oral terbinafi ne. Methods Terbinafine was given at the following doses: in children weighing < 20 kg, 62.5 mg daily; 20-40 kg, 125 mg daily; > 40 kg, 250 mg daily, Two hundred and ten children aged 2-16 years, with mycologically confirmed tine a capitis, were randomized to 4 weeks treatment with terbinafine or 8 weeks with griseofulvin, and followed for a total of 24 weeks to determine the d ifference between treatments with respect to short- and long-term efficacy and tolerability, Results One hundred and forty-seven patients were evaluable (terbinafine 77 , griseofulvin 70), Although the 4-week course of terbinafine resulted in a trend to more rapid clearance of tinea capitis, there were no statisticall y significant differences between the two drugs in terms of overall outcome or tolerability, apart from in a subgroup of patients with Trichophyton in fections, and weighing > 20 kg, who responded better to terbinafine than to griseofulvin at 4 weeks. By contrast, there was a better response to grise ofulvin than to terbinafine in patients with Microsporum audouinii infectio ns, Conclusions Overall, the study showed that 4 weeks of treatment with oral t erbinafine has similar efficacy to 8 weeks of treatment with griseofulvin f or the management of tinea capitis in children.