Angiosarcoma of the scalp: absence of vascular endothelial cadherin in primary and metastatic lesions

A 73-year-old man with angiosarcoma of the scalp died about 1 year after di sease onset, despite systemic and topical administration of recombinant int erleukin-2. Histopathology showed typical changes of endothelial cells with very sparse lymphocytic infiltration into the tumour. An autopsy revealed that the primary site penetrated cranial bone and invaded vertically into t he subarachnoid space. Multiple metastases to lung, chest wall, vertebrae a nd ribs were also found. On immunofluorescence staining, the expression of vascular endothelial cadherin, which is present in normal endothelium, was absent from both primary and metastatic sites. This may have promoted local invasion and metastasis.