Focal nodular hyperplasia is a rare, benign condition of the liver. A 28-ye
ar-old woman with malignant melanoma, mild liver enzyme abnormalities, stea
tohepatitis and newly documented hepatic lesions is described. Ultrasound c
omputed tomography and magnetic resonance imaging suggested only areas of f
ocal fatty sparing but could not eliminate the concern for metastases. A (9
9m)technetium-labelled sulphur colloid scan, however, revealed areas of inc
reased uptake consistent with multiple local nodular hyperplasia. This diag
nosis was ultimately confirmed with a liver biopsy. The investigation of a
patient with a malignancy and expanding hepatic lesions is challenging. Thi
s cast illustrates the usefulness of the (99)mtechnetium-labelled sulphur c
olloid scan in the evaluation of patients with hepatic lesions.