Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

Authors
Kamal, A Laxman, N Ramesh, G Neelima, K Kondapi, AK
Citation
A. Kamal et al., Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity, CHEM COMMUN, (5), 2001, pp. 437-438
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
5
Year of publication
2001
Pages
437 - 438
Database
ISI
SICI code
1359-7345(2001):5<437:SONNPW>2.0.ZU;2-9
Abstract
Mixed imine-amide pyrrolobenzodiazepine dimers have been prepared which exh ibit potent antitumour activity and have significant DNA binding affinity; one of them, 1c, has been shown to cause a remarkable rise in the melting t emperature of calf thymus DNA.