Nutrition is an important factor for the normal functions of the immun
e system. This interrelationship has been demonstrated in various clin
ical studies. However, there are currently only few data available on
the mechanisms by which excess or deficiency of energy and single nutr
ients may affect the immune system. This review summarizes the present
knowledge on how energy, proteins, carbohydrates including alcohol as
well as lipids may affect immune mechanisms. In addition, the functio
ns of micronutrients (vitamin A, D, E, C, B6, iron, zinc, selenium) fo
r the immune system as well as the consequences of single nutrient def
iciencies and of micronutrient supplementation are discussed. In concl
usion, an adequate nutrition facilitates the normal functioning of the
immune system and may reduce the risks of immunologically mediated di
seases.