Kohamaic acids A and B, novel cytotoxic sesterterpenic acids, from the marine sponge Ircinia sp.

Authors
Kokubo, S Yogi, K Uddin, MJ Inuzuka, T Suenaga, K Ueda, K Uemura, D
Citation
S. Kokubo et al., Kohamaic acids A and B, novel cytotoxic sesterterpenic acids, from the marine sponge Ircinia sp., CHEM LETT, (2), 2001, pp. 176-177
Citations number
3
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
2
Year of publication
2001
Pages
176 - 177
Database
ISI
SICI code
0366-7022(20010205):2<176:KAAABN>2.0.ZU;2-#
Abstract
Two new sesterterpenic acids, which exhibited moderate cytotoxicity, were i solated from the marine sponge Ircinia sp. Their absolute stereochemistries were determined by spectroscopic and chemical analyses. Their configuratio ns at C15 were different from those of previously isolated sesterterpenes. This result suggests the existence of a (14Z)-geranylfarnesyl pyrophosphate , which is yet unknown in nature.