Treatment of chronic hepatitis C with amantadine hydrochloride in patientswho had not responded to previous treatment with interferon-alpha and/or ribavirin

Authors
Di Martino, V Boudjema, H Delacour, T Cazier, A Caron, C Coutarel, P Dumouchel, P Cadranel, JF
Citation
V. Di Martino et al., Treatment of chronic hepatitis C with amantadine hydrochloride in patientswho had not responded to previous treatment with interferon-alpha and/or ribavirin, CLIN INF D, 32(5), 2001, pp. 830-831
Citations number
8
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
32
Issue
5
Year of publication
2001
Pages
830 - 831
Database
ISI
SICI code
1058-4838(20010301)32:5<830:TOCHCW>2.0.ZU;2-9
Abstract
Seven women and 3 men infected with hepatitis C virus, all of whom had fail ed to respond to therapy with either IFN-alpha or IFN and ribavirin, were t reated with 200 mg/day of amantadine hydrochloride for 12 months. We found a significant decrease of serum ALT activity without any decrease in virus load. These results suggest that amantadine hydrochloride should not be use d as monotherapy for patients who do not respond to treatment with IFN-alph a and/or ribavirin.