Isolation of antibacteriologically active compounds from species of the Cottidae family

Antibacteriologically active compounds were isolated from the skin of sever al species of the fish family Cottidae. Suitable samples were obtained from species living in the Pacific, lakes in North America and the Fenno-Scandi navian peninsula as well as the Baltic sea. The compounds isolated from the skin of Triglops quadricornis (fourhorn sculpin) from the Baltic sea were particularly studied. The activity was partially characterised by chemical and biochemical investigations and the susceptibility of several human and fish pathogens described. The substance or substance(s) are of a high molec ular mass, resist proteolytic and glycolytic enzymes, are heat and pH sensi tive and water soluble (C) 2001 Elsevier Science Ltd. All rights reserved.