Purpose. To describe corneal intrastromal epithelial cysts and present a mi
nimally invasive surgical technique successfully used to treat such a lesio
n. Methods. A 5-year-old girl with a progressive, vision-threatening, intra
stromal corneal opacity in the left eye is described. The patient had a his
tory of accommodative esotropia and bilateral medial rectus recession two y
ears before presentation. A presumptive diagnosis of an epithelial cyst sec
ondary to iatrogenic seeding of the limbal corneal stroma was made. Because
of documented growth toward the visual axis and a decrease in best-correct
ed visual acuity, surgical treatment was initiated. The cyst was incised an
d debrided through a 2.0-mm, partial-thickness, limbus-parallel, clear corn
eal incision. Results. Cytologic analysis of the cyst contents showed intac
t and degenerated epithelial cells, thereby confirming the diagnosis. The c
yst walls were scraped through the nonenlarged incision, and irrigation res
ulted in nearly complete clearing of the opacity. Stable vision and no recu
rrences were documented with 21 months of follow-up. Conclusion. This minim
ally invasive surgical approach may be a good alternative to previously des
cribed treatments for intrastromal corneal cysts.