Progress in biosensors has mainly been made by the improvement of the biolo
gical components and the implementation of microsystem technologies. Enzyme
s are still the most appropriate recognition elements because they combine
high chemical specificity and inherent biocatalytic signal amplification. A
breakthrough has been achieved in the application of membrane-integrated r
eceptor systems for analyte recognition and signal transduction in biosenso
rs. Sensor integration of RNA aptamers has been initiated, and the performa
nce of fully synthetic molecularly imprinted polymers has been improved.